At least 538 people have been killed in a sweeping crackdown on nationwide protests in Iran, activists said, as Tehran warned the United States and Israel against any move to intervene in support of demonstrators.

Israeli Prime Minister Benjamin Netanyahu expressed support for Iranian protesters, condemned killings, and voiced hope for a liberated Iran, as Tehran warned the US and Israel amid escalating unrest.

Iran's foreign minister says his country does not want war with Israel or the U.S., but is ready to fight back if attacked

Iran has executed a man convicted of spying for Israeli Mossad. A report by the official IRNA news agency Wednesday identifies the man as Ali Ardestani, saying he relayed sensitive information to Mossad officers in return for financial rewards in the form of cryptocurrencies.

Violence surrounding the demonstrations has killed at least 116 people, while 2,600 have been detained, according to activists.

US secretary of state Marco Rubio and Israel's Benjamin Netanyahu have reportedly discussed a possible American intervention in Iran against the backdrop of escalating anti-government protests in the country.

Tehran warned the U.S. and Israel against any intervention over nationwide protests in Iran while it sought to placate its citizens, as demonstrations entered their third week and fatalities mounted.

Ex-diplomat Anil Trigunayat warns Iran faces a volatile crossroads, with the US seeking nuclear deal leverage while Israel pushes for regime change, creating high-stakes regional and economic implications.