Panel A shows the lineage of mutations that have been identified in the omicron BA.1, BA.2, BA.2.12.1, and BA.4 or BA.5 subvariants of SARS-CoV-2, as compared with the reference WA1/2020 isolate. BA.4 ...
With declining SARS-CoV-2-specific antibody titers and increasing numbers of spike mutations, the ongoing emergence of Omicron subvariants causes serious challenges to current vaccination strategies.
To assess the antigenicity of the BA.2.86 spike, we constructed vesicular stomatitis virus (VSV) pseudotyped viruses using both versions of the spike gene as well as BA.2, XBB.1.5 and EG.5.1 ...
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