Abl is a non-receptor tyrosine kinase that contains a Src-homology-3 (SH3)- and a Src-homology-2 (SH2)-domain. Abl participates in many signalling pathways in the cytoplasm and the nucleus. The ...
Chronic myelogenous leukaemia (CML) results from the neoplastic transformation of a haematopoietic stem cell. Clinical and laboratory studies indicate that the fusion protein BCR–ABL is essential for ...
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