A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, ...

It will be interesting to see where companies developing therapeutics based on epigenome editing technology choose to focus their development efforts over the next few years. For Moonwalk Biosciences ...

Epigenetics refer to DNA modifications that may affect phenotype but don’t alter the nucleotide sequence itself. Epigenetic changes can often be passed down generations, hence the Greek prefix “epi”, ...

Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription ...

Epigenome editing has followed a similar path, in that more recent technological breakthroughs have enabled scientists to apply the discoveries made in previous decades. Epigenome editing performs a ...

In a study published in Nature Biotechnology, researchers have enhanced the genome editing capabilities of Obligate Mobile Element Guided Activity (OMEGA)-IscB, an endonuclease protein, through ...

Recent scientific advances have made genome editing technologies—a suite of biological tools for making precise additions, deletions, and alterations to the DNA and RNA of living cells– more rapid, ...

A one-off injection might be able to permanently reduce the risk of heart disease by reversibly switching off a gene in the liver, according to a study in mice. The findings suggest that the approach ...

Creative depiction of the epigenetic editing toolkit: each building represents the epigenetic state of a single gene (dark windows are silenced genes, lit up windows are active genes). The crane ...

Genes are regulated by complex interactions involving transcription factors, DNA regulatory regions, and epigenetic modifications which alter chromatin structure. Modifications to chromatin regulate ...