The rapid increase in type 2 diabetes (T2D) incidence results from a combination of lifestyle factors and genetics. Recent genome-wide association studies have identified close to 50 loci associated ...

Endocytosis and exocytosis are the processes by which cells move materials into or out of the cell that are too large to directly pass through the lipid bilayer of the cell membrane. Large molecules, ...

Functional studies on secretory cells have supplied ample evidence that synaptic and other secretory vesicles can exist in distinct functional states 1,2,3,4. Typically, only a fraction of all ...

Every time a hormone is released from a cell, every time a neurotransmitter leaps across a synapse to relay a message from one neuron to another, the cell must undergo exocytosis. This is the process ...

A study has identified a key activation mechanism that leads to vesicle fusion to the plasma membrane, a part of exocytosis. Every time a hormone is released from a cell, every time a neurotransmitter ...