One of the key features of depression is the lack of motivation to do things that you know you should really do. For example, you may think that you don't have the motivation to exercise, or spend ...

A new study published this week in Molecular Psychiatry by Emory University researchers has revealed a promising new avenue for treating motivational deficits in patients suffering from depression.

Philadelphia, May 1, 2025 – New research shows that individuals who have recovered from depression are generally less willing to exert effort to pursue potential rewards compared to those who have ...

Deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle (MFB), which is linked to reward and motivation, revealed metabolic brain changes over 12 months post-DBS ...

Depression can make getting out of bed in the morning difficult and powering through a work day feel near-impossible. Symptoms of depression—fatigue, persistent anxiety and sadness, and feelings of ...

If you struggle with depression, you probably know how heavy it can feel, as if an invisible weight is pulling you down. One of the most painful ironies of depression is that it often drains people of ...

Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors ...