An investigative treatment targeting APOL1 activity significantly improved proteinuria APOL1-mediated kidney disease (AMKD), a proof-of-concept phase IIa study found. In a single-arm, open-label study ...
VIENNA — Sibeprenlimab, a novel selective immune antibody, reduced the urine protein-to-creatinine ratio (uPCR) by more than half in patients with immunoglobulin A (IgA) nephropathy, according to an ...
A subset of patients receiving triple immunosuppressive therapy with voclosporin, mycophenolate mofetil, and low-dose glucocorticoids can achieve lower proteinuria targets. Voclosporin treatment can ...
October 2025: We updated recommendations 1.1 and 1.2 to change the unit for urine protein-to-creatinine ratio (UPCR) to mg/mmol from g/g. A UPCR of 85 mg/mmol or more equates to the 0.75 g/g or more ...
Patients with IgA nephropathy had an elevated risk for adverse kidney outcomes starting at proteinuria levels of 0.5 g/g. In patients with immunoglobulin A nephropathy (IgAN), higher levels of ...
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