The Dodgers and Padres squared off this week in their first of four 2025 regular-season series and the first rematch since the Southern California foes faced off in last year’s NLDS. With the Dodgers holding a one-game lead on both the Padres and Giants atop the NL West entering the series, the stakes were readily apparent.

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The LA Dodgers (40-28) battle the San Diego Padres (38-28) in the rubber match of their 3-game series on Wednesday. First pitch from Petco Park is scheduled for 4:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Dodgers vs. Padres odds and make our expert MLB picks and predictions for the best bets.