A female-led Pirates of the Caribbean 6 starring Margot Robbie has been discussed. Though Robbie later said the film was no longer in development, Bruckheimer has still sometimes mentioned it as a possibility. There were also rumors of Disney hoping to cast Karen Gillan in a sixth film.

In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,

Johnny Depp reportedly is considering a return to one of his most popular roles: Captain Jack Sparrow. Pirates of the Caribbean Producer Jerry Bruckheimer tells EW that he’s had talks with Depp about reprising the swashbuckling character in a sixth Pirates film.