Imaging Chromatin to Deduce Function from Form Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.

The nucleoli are not the only small structures found in the nucleus -- others include nuclear speckles and the nuclear lamina, an envelope that surrounds the genome and can bind to chromatin.

This revealed how axons release serotonin onto ciliary receptors, triggering a cascade of chemical reactions that signal chromatin opening and genomic changes in the nucleus. Therefore, the signal ...

To overcome the problem of visualizing chromatin in an intact nucleus, O'Shea's team screened a number of candidate dyes, eventually finding one that could be precisely manipulated with light to ...

Studies are centered on the novel geo-spatial convergence of chromatin modifiers, often lost in renal cell carcinoma, outside their traditional habitat of chromatin in the nucleus. We are ...

Interestingly most of the epigenetic modifications that shape chromatin are erased and have to be established de novo. In Drosophila, the lab of Nicola Iovino had previously shown that after ...

Their research, published on the cover of Nature Biomedical Engineering on Dec. 2 and titled "Nuclear Deformation Guides Chromatin Reorganization in Cardiac Development and Disease," found that ...

Moreover, the physiological function of FUS in the nucleus remains to be fully understood. In this study, we found that a significant portion of nuclear FUS was bound to active chromatin and that the ...

It is proposed that elongation of the nucleus in spermatids of Marchantia results from interaction between its membranous envelope and microtubules of the spermatid's cytoskeleton. The nucleus may be ...