National University of Singapore (NUS) researchers have devised a method to safely and temporarily "switch off" and then "turn on" ribonucleic acid (RNA) inside cells. This is achieved using ...

An extensively studied function of NLRs is their involvement in the formation and activation of inflammasomes, a signaling pathway mediating activation of caspase-1 and secretion of inflammatory ...

RFC depletion experiments and use of linear DNAs indicate that RFC function in endonuclease activation is limited to PCNA loading. Whereas nicked circular heteroduplex DNA is a good substrate for PCNA ...