Ca 2+ /calmodulin regulates TRPA1 in cells via its C-lobe To initially ask whether CaM can directly regulate TRPA1, we assayed wild type (WT) human TRPA1 (hTRPA1) for its ability to bind CaM-agarose ...
Centre for Biomolecular Sciences and School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K. Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health ...
Biotechnological-Biomedical Center, Faculty of Chemistry and Mineralogy, University of Leipzig, D-04103 Leipzig, Germany, and Laboratory of Chemical Physics, Building 5, National Institute of Diabetes ...
Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled ...
Calmodulin dysfunction in neurological disorders. Schematic view of how alterations in calmodulin (CaM)-dependent signaling contribute to neurological diseases. In Alzheimer’s disease (AD), amyloid-β ...
The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential ...
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