Nature

Integration of multiple machine learning approaches develops a gene mutation-based classifier for accurate immunotherapy outcomes

In recent years, the advent of immune checkpoint blockade (ICB) targeting programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), and cytotoxic T lymphocyte-associated protein-4 (CTLA-4) has ...
Nature

Machine learning identifies TIME subtypes linking EGFR mutations and immune states in lung adenocarcinoma

Lung cancer is the leading cause of cancer-related death worldwide, with non-small cell lung cancer (NSCLC) accounting for ~85% of newly diagnosed lung cancer cases 1,2,3. Lung adenocarcinoma (LUAD) ...