After decades of debate, the Food and Drug Administration (FDA) has announced a ban on Red Dye No. 3, a synthetic food coloring that’s been linked to cancer in male lab rats. The decision comes after a petition filed in 2022 by advocacy groups,

Red dye No. 3 has been permissible for use in food despite the Delaney Clause of the FDA’s Federal Food, Drug, and Cosmetic Act. The clause, in part, “prohibits the FDA from approving a color additive that is ingested if it causes cancer in animals or humans when ingested,” according to the agency .

T he U.S. Food and Drug Administration has banned the use of red dye No. 3 in foods, more than three decades after researchers discovered its link to cancer in rodents and to worsened attention deficit and hyperactivity disorder and other behavioral symptoms. The dye is already banned from foods in the European Union, New Zealand and Australia.