Bills vs. Jaguars odds, prediction, time: NFL picks, Monday Night Football bets from model on 41-22-roll
The Bills are 5.5-point favorites in the latest Jaguars vs. Bills odds, while the over/under for total points scored is 45.5. Before making any Bills vs. Jaguars picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.