The EMBO Journal29d
DSTYK phosphorylates STING at late endosomes to promote STING signaling
Stimulator of interferon genes (STING) is essential for innate immune pathway activation in response to pathogenic DNA. Proper activation of STING signaling requires STING translocation and ...
C&EN1mon
Pathway Elucidation and Key Enzymatic Processes in the Biodegradation of Difenoconazole by Pseudomonas putida A-3
Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan ...
eLife7mon
Discovery of the 1-naphthylamine biodegradation pathway reveals a broad-substrate-spectrum enzyme catalyzing 1-naphthylamine glutamylation
Herein, we describe a pathway for 1NA degradation in the isolate Pseudomonas sp. strain JS3066, determine the structure and mechanism of the enzyme NpaA1 that catalyzes the initial reaction, and ...
Frontiers2y
Sodium acetate regulates milk fat synthesis through the activation of GPR41/GPR43 signaling pathway
Milk fat is positively related to the concentration of acetate in the blood, while the underlying mechanism is still unclear. Objective: This study is to investigate the effects of sodium acetate ...
Frontiers2y
Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab
Moreover, Asu plays an important role in the protein degradation pathways, asparagine deamidation, and aspartic acid isomerization. Here, Asu modification with a high abundance in the framework region ...
eLife8y
A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising ... tag ...