BG, blood glucose; CHO, carbohydrate; CGMS, continuous glucose monitoring system; DT, daily total; PDM, personal diabetes manager; TBR, temporary basal rate.

Unwell children attending emergency department 4.9% CRP<5 mg/L 1.5% ...

Rheumatological Juvenile idiopathic arthritis (various subtypes) Interferonopathies Systemic lupus erythematosus ...

ADHD, attention-deficit hyperactivity disorder; OCD, obsessive-compulsive disorder; TS, Tourette syndrome.

All adverse respiratory events 67/241 (27.8%) 114/238 (47.9%) 2.4 (1.6 to 3.5) Laryngospasm 12/241 (5.0%) 28/238 (11.8%) 2.5 (1.3 to 5.1) Cough 27/241 (11.2%) 79/238 (33.2%) 3.9 (2.4 to 6.4) ...

Californian Birth Defects Monitoring Programme Tricuspid valve defects 20% ...

Obtain biochemical investigation before starting treatment, but do not unduly delay treatment. Consider admission to a paediatric high dependency unit or intensive care and monitor vital signs ...

†In primary adrenal insufficiency only.

CYP11A (P450 SCC), P450 oxidoreductase deficiency; CYP21, 21-hydroxylase; HSD3B2, 3β-hydroxysteroid dehydrogenase; DAX-1, dosage-sensitive sex reversal, adrenal hypoplasia congenital critical region ...

Bilateral: predominantly lower limb spasticity. Prematurity. Prenatal (third trimester) IVH. Periventricular white matter. Cognition may be well preserved, epilepsy unlikely. Bilateral:predominantly ...

Vitiligo Localised: cosmetic camouflage, topical corticosteroids +/− calcipotriol, or tacrolimus Good for limited disease of the face and hair-bearing areas; may be poor for widespread disease or on ...

Outcome Extended course group, n=114 Standard course group, n=109 Key outcome (95%CI) ...