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Low cortisol, medically referred to as hypocortisolemia, is a physiological state characterized by an abnormally reduced concentration of the glucocorticoid hormone cortisol in the bloodstream relative to the levels required for normal metabolic, cardiovascular, neurological, and immune system function. Cortisol is a steroid hormone synthesized and secreted by the zona fasciculata of the adrenal cortex under regulation of the hypothalamic–pituitary–adrenal (HPA) axis. Its production is stimulate
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