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One thing that often surprises people with mast cell activation is how we use antihistamines. In MCAS, we frequently use much higher doses than the FDA-approved allergy doses: • Famotidine: 40 mg twice daily • Zyrtec (cetirizine): 20 mg twice daily • Allegra (fexofenadine): 180 mg twice daily For many people, simply pushing the dose up (safely and intentionally) can make a meaningful difference. That said — this doesn’t help everyone. And that’s important to know. If antihistamines don’t work fo
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